Senescence Staining Assay, Catalog: COS-0102

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COS 0102 DS
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COS 0102 SDS
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PRODUCT SUMMARY

Catalog COS-0102

Size To stain 4X 24-, 12-, 6-well plates

Sample Type Cultured Adherent Cells

Species All

Method of Detection Light Microscopy

Assay Type Qualitative

Application To detect β-Gal activity in senescent cells under a light  microscope.

Storage Conditions 4°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

DESCRIPTION

Cellular Senescence is the phenomenon wherein cells stop dividing. It can be induced by both internal (oxidative stress, DNA damage, etc.) and external (toxins, UV light, etc.) factors Senescence is a state of arrested growth in which cells remain viable but stop dividing. Senescent cells display increase of cell size, senescence-associated expression of β-galactosidase, p53 and P16 activity, along with altered patterns of gene expression. AkrivisBio’s Senescence Detection Kit is designed to detect β-Gal activity. β-Gal is present primarily in senescent cells but can give a false positive with cells that normally express β-gal such as mature macrophages.