PicoSense Glutamate Carboxypeptidase II Activity Assay, Catalog: MA-0407

Catalog MA-040

Size 100 wells

Sample Type Purifed Enzyme, Protein Preparations, Tissue Lysate

Method of Detection 100 wells, Fluorometric, Ex/Em = 535/587 nm

Application A simple, sensitive plate based Fluorimetric assay to measure Glutamate Carboxypeptidase II activity in a variety of sample types.

Sensitivity < 1 µUnit per well

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Glutamate Carboxypeptidase II also known as NAALADase, prostate-specific membrane antigen (PSMA) or folate hydrolase (FOLH1)] is a membrane-bound zinc-metalloenzyme with roles in neurobiology and cancer progression. It is highly expressed in the nervous system, prostate, kidney and jejunal brush border membranes. In the CNS, it hydrolyzes NAAG, the 3^rd most prevalent neurotransmitter, forming glutamate. Upregulation can result in glutamate excitotoxicity, leading to neuronal damage and death. In the prostate, Highly expressed in carcinoma, it is a key diagnostic and therapeutic target. It is also highly upregulated in IBD implicating it in the etiology of this disease. AkrivisBio’s PicoSense Glutamate Carboxypeptidase II Activity Assay is a simple, sensitive way to measure GCPII activity in a variety of sample types with a sensitivity well below 1 µUnit per well.