Neuraminidase Activity Assay, Catalog: MA-0325

Catalog MA-0325

Size 100 wells

Sample Type Cell or Tissue Lysates, Culture Media, Urine, Serum, Other Biological Fluids

Method of Detection Fluorometric, Ex/Em = 535/587 nm

Assay Type Quantitative

Application A simple, sensitive plate-based fluorometric assay to measure neuraminidase activity in a variety of biological sample types.

Sensitivity In the low µUnit range

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Neuraminidase hydrolyzes terminal sialic acid residues from glycoproteins, glycolipids and oligosaccharides, which contribute to a range of physiological and pathological processes. In mammals, 4 main types of neuraminidases (NEU1-4) display different tissue distributions, subcellular locations and substrate specificities. Neuraminidases regulate metabolism by affecting glycoprotein and glycolipid turnover in the lysosome. NEU1 modulates cell receptors by desialylating them which can change receptor activity and downstream signaling pathways. Neuraminidase dysfunction appears to be involved in a variety of disease state from some lysosomal storage diseases, type 2 diabetes, neurodegenerative disorders, some cancers, cardiovascular disease and respiratory pathologies. AkrivisBio’s Neuraminidase Activity Assay is a simple, sensitive way to measure neuraminidase activity in a variety of biological sample types, with a sensitivity in the low µUnit range.