ACE 1 Inhibitor Screening Kit, Catalog: MA-0188

Catalog MA-0188

Size 100 wells

Sample Type Samples containing drugs, inhibitors or ligands (compounds that can interact and affect ACE1 activity).

Method of Detection Colorimetric, OD 345 nm 

Assay Type Quantitative

Application A plate based simple, colorimetric assay to evaluate compounds for their effect on ACE1 enzyme activity.

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Angiotensin-I-converting enzyme (ACE1) is a zinc-dependent peptide carboxypeptidase that catalyzes the conversion of angiotensin I to angiotensin II, removing a carboxy-terminal dipeptide. ACE is a part of the renin/angiotensin system. It also degrades bradykinin and other vasoactive peptides. Chronic activation of the ACE/AngII/AT1 receptor axis favors adiposity, oxidative stress, low-grade inflammation and insulin resistance.. ACE inhibitors result in a decrease in sodium retention, aldosterone secretion, sympathetic activation and vascular remodeling. They also result in enhanced glucose disposal partly via  IRS-1 phosphorylation, PI3K activity and increased GLUT4. Pharmacologically, ACE inhibitors are used for hypertension, and resulting heart failure, stroke, etc. AkrivisBio’s ACE1 Inhibitor Screening kit is a simple way to evaluate compounds for their effect on ACE1 enzyme activity.