Cyclooxygenase-1 (COX-1) Inhibitor Screening Kit, Catalog: MA-0215
US$475.00
100 wells, Fluorometric, Ex/Em 535/587 nm
100 wells, Fluorometric, Ex/Em 535/587 nm
Catalog MA-0215
Size 100 wells
Sample Type Test Inhibitor compounds
Method of Detection Fluorometric, Ex/Em = 535/587 nm
Assay Type Quantitative
Application A simple, sensitive assay to screen, study and characterize COX-1 inhibitors.
Storage Conditions -20°C
Shipping Temperature Gel Pack
Shelf Life One year from the date of delivery
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain. AkrivisBio’s COX-1 Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of COX-1 inhibitors. The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.