Phytosphingosine, Catalog: 2426

Alternate Names 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS

Appearance White solid

CAS # 554-62-1

Molecular Formula C₁₈H₃₉NO₃

Molecular Weight 317.51

Purity ≥98% by TLC

Solubility EtOH (~ 2 mg/ml)

SMILES CCCCCCCCCCCCCCC(C(C(CO)N)O)O

InChi InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1

InChi Key AERBNCYCJBRYDG-KSZLIROESA-N

PubChem CID 122121

MDL Number MFCD06804643

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Phytosphingosine is a phospholipid structurally like Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities.