OTS-964, Catalog: B1964

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(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one

PRODUCT SUMMARY

Alternate Name (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one

Appearance Crystalline solid

CAS # 1338545-07-5

Molecular Formula C₂₂H₂₂N₂O₂S

Molecular Weight 378.49

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES CC(CN(C)C)C1=CC=C(C=C1)C2=C(C=CC3=C2C4=C(C(=O)N3)SC=C4)O

InChi InChI=1S/C22H22N2O2S/c1-13(12-24(2)3)14-4-6-15(7-5-14)19-18(25)9-8-17-20(19)16-10-11-27-21(16)22(26)23-17/h4-11,13,25H,12H2,1-3H3,(H,23,26)/t13-/m0/s1

InChi Key WGYWHJPQFQGLOQ-ZDUSSCGKSA-N

PubChem CID 67449676

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

OTS-964 is a potent inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS-964 induces apoptosis of human lung cancer cells in mouse xenografts.