BAY-1895344 hydrochloride, Catalog: B1962

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(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride

PRODUCT SUMMARY

Alternate Name (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride

Appearance Yellow solid

CAS # 1876467-74-1 (free base)

Molecular Formula C₂₀H₂₂ClN₇O 

Molecular Weight 411.89

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C

InChi InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1

InChi Key YBXRSCXGRPSTMW-CYBMUJFWSA-N

PubChem CID 118869362

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.