AGI-5198, Catalog: 2369

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N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide; IDH-C35

PRODUCT SUMMARY

Alternate Names N-​[2-​(cyclohexylamino)-​1-​(2-​methylphenyl)-​2-​oxoethyl]-​N-​(3-​fluorophenyl)-​2-​methyl-​1H-​imidazole-​1-​acetamide; IDH-C35

Appearance Crystalline solid

CAS # 1355326-35-0

Molecular Formula C₂₇H₃₁FN₄O₂

Molecular Weight 462.56

Purity ≥ 98% by HPLC

Solubility DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)

SMILES CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

InChi InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)

InChi Key FNYGWXSATBUBER-UHFFFAOYSA-N

PubChem CID 56645356

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

 

DESCRIPTION

A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression.