PZ-2891, Catalog: B2460

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PZ2891; 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile

PRODUCT SUMMARY

Alternate Names PZ2891; 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile

Appearance Crystalline solid

CAS # 2170608-82-7

Molecular Formula C₂₀H₂₃N₅O

Molecular Weight 349.44

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1

InChi InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3

InChi Key LGWDVWIZDPGCFG-UHFFFAOYSA-N

Storage Conditions -20ºC

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

PZ-2891 (PZ2891) a specific, allosteric, brain-permeable, pantothenate kinase (PANK) modulator. it acts as both an orthosteric inhibitor (IC₅₀ =1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.