INCB-024360, Catalog: 9477

IN STOCK!
US$0.00

(E)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide); Epacadostat; INCB24360

PRODUCT SUMMARY

Alternate Names (E)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide); Epacadostat; INCB24360

Appearance White to off-white solid

CAS # 1204669-58-8

Molecular Formula C₁₁H₁₃BrFN₇O₄S

Molecular Weight 438.23

Purity ≥ 98% by HPLC

Solubility DMSO (>40 mg/ml)

SMILES C1=CC(=C(C=C1N/C(=C\2/C(=NON2)NCCNS(=O)(=O)N)/N=O)Br)F

InChi InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16-17,19H,3-4H2,(H,15,20)(H2,14,22,23)/b11-9+

InChi Key YPBKTZBXSBLTDK-PKNBQFBNSA-N

PubChem CID 44608567

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

INCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities.