WP-1130, Catalog: 2014

Alternate Names (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; Degrasyn

Appearance Pale yellow solid

CAS # 856243-80-6

Molecular Formula C₁₉H₁₈BrN₃O

Molecular Weight 384.27

Purity ≥ 98% by TLC

Solubility DMSO (40 mg/ml) or EtOH (25 mg/ml)

SMILES CCCC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

InChi InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1

InChi Key LIDOPKHSVQTSJY-VMEIHUARSA-N

PubChem CID 11222830

Storage Conditions -20°C

Shipping Conditions Gel Pack 

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

Cell-permeable, WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination.