CDE-096, Catalog: B2663

Alternate Names CDE096; 3-(((3-(trifluoromethyl)phenoxy)carbonyl)amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate)

Appearance Crystalline solid

CAS # 1228357-04-7

Molecular Formula C₂₅H₂₀F₃NO₁₂

Molecular Weight 583.42

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES O=C(NCC(OC(C1=CC(O)=C(O)C(O)=C1)=O)COC(C2=CC(O)=C(O)C(O)=C2)=O)OC3=CC=CC(C(F)(F)F)=C3

InChi InChI=1S/C25H20F3NO12/c26-25(27,28)13-2-1-3-14(8-13)41-24(38)29-9-15(40-23(37)12-6-18(32)21(35)19(33)7-12)10-39-22(36)11-4-16(30)20(34)17(31)5-11/h1-8,15,30-35H,9-10H2,(H,29,38)

InChi Key OXWKLJPAKUDPJY-UHFFFAOYSA-N

PubChem CID N/A

Storage Conditions -20ºC

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

CDE-096 is a high affinity, synthetic inactivator of plasminogen activator inhibitor-1 (PAI-1). CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding to both proteases and vitronectin. This allosteric mechanism is characterized by reciprocal communication between the high-affinity compound-binding and vitronectin-binding sites.