STIMA-1, Catalog: 9437

Alternate Names 2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis

Appearance Off-white solid

CAS # 91634-12-7

Molecular Formula C₁₀H₈N₂O

Molecular Weight 172.19

Purity ≥ 97%

Solubility DMSO

SMILES C=CC1=NC(=O)C2=CC=CC=C2N1

InChi InChI=1S/C10H8N2O/c1-2-9-11-8-6-4-3-5-7(8)10(13)12-9/h2-6H,1H2,(H,11,12,13)

InChi Key VCHFWHQHIKFOIC-UHFFFAOYSA-N

PubChem CID 3801471

MDL Number MFCD04037877

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.