AZ-5104, Catalog: 9441

Alternate Names N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

Appearance Off-white solid

CAS # 1421373-98-9

Molecular Formula C₂₇H₃₁N₇O₂

Molecular Weight 485.58

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC

InChi InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12,15-17,29H,1,13-14H2,2-5H3,(H,30,35)(H,28,31,32)

InChi Key IQNVEOMHJHBNHC-UHFFFAOYSA-N

PubChem CID 71496460

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

AZ-5104 is an active, demethylated metabolite of AZD-9291 (Cat.No.2674). It displays similar overall activity profile with AZD-9291, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD-9291, AZ-5104 displays potent antitumor activities both in vitro and in vivo.