Quinol 1h, Catalog: 2436

Alternate Name 4-(1-Benzenesulfonyl-6-fluoro-1H-indol-2-yl)-4-hydroxy-cyclohexa-2,5-dienone

Appearance Crystalline solid

Molecular Formula C₂₀H₁₄FNO₄S

Molecular Weight 383.4

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES O=C(C=C1)C=CC1(O)C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=CC=C3

InChi InChI=1S/C20H15NO4S/c22-16-10-12-20(23,13-11-16)19-14-15-6-4-5-9-18(15)21(19)26(24,25)17-7-2-1-3-8-17/h1-14,23H

InChi Key HWKQYGBAAMKHDY-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Quinol 1h is a potent and selective antitumor agent that displays potent activity against renal, colon, and breast cancer cell lines in the NCI 60-cell panel. Exhibits a mean GI₅₀ of 16 nM and a mean LC₅₀ value of 2.24 µM in NCI60-cell-line screen, with LC₅₀ activity in the HCT 116 human colon cancer cell line below 10 nM.