CAY10683, Catalog: B1051

Alternate Names EthylN-[4-oxo-4-(2-phenylethylamino)butyl]carbamate; Santacruzamate A

Appearance Crystalline solid

CAS # 1477949-42-0

Molecular Formula C₁₅H₂₂N₂O₃

Molecular Weight 278.35

Purity ≥ 98% by HPLC

Solubility DMSO (~25 mg/ml)

SMILES CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1

InChi InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)

InChi Key HTOYBIILVCHURC-UHFFFAOYSA-N

PubChem CID 72946782

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca. It inhibits HDAC2 and HDAC6 with IC₅₀ values of 0.119 and 434 nM, respectively. Inhibits HDAC4 only at higher concentrations (IC₅₀ = >1,000 nM). CAY10683 inhibits the growth of HCT-116 colon cancer cells and HuT-78