BMS-863233 hydrochloride, Catalog: 2598

Alternate Names (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride; XL-413 hydrochloride

Appearance White to off-white solid

CAS # 1169562-71-3

Molecular Formula C₁₄H₁₃Cl₂N₃O₂

Molecular Weight 326.17

Purity > 98% by HPLC

Solubility H₂O (~ 6.5 mg/ml)

SMILES C1CC(NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl

InChi InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1

InChi Key JJWLXRKVUJDJKG-VIFPVBQESA-N

PubChem CID 57899889

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.