MK-571 sodium, Catalog: 2692

Alternate Names (E)-​3-​[[[3-​[2-​(7-​chloro-​2-​quinolinyl)ethenyl]phenyl][[3-​(dimethylamino)-​3-​oxopropyl]thio]methyl]thio]-​propanoic acid, sodium salt; L-660,711

Appearance Off-white solid

CAS # 115103-85-0

Molecular Formula C₂₆H₂₆ClN₂O₃S₂.Na

Molecular Weight 537.07

Purity ≥ 95%

Solubility DMSO (~10 mg/ml) or PBS (pH 7.2, ~10 mg/ml)

SMILES CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)[O-].[Na+]

InChi InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);/q;+1/p-1/b10-6+;/t26-;/m1./s1

InChi Key XNAYQOBPAXEYLI-LQKFMROPSA-M

PubChem CID 44322990

MDL Number MFCD11114392

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

MK-571 sodium is the sodium salt of the multidrug resistance protein-1 (MRP1) inhibitor MK-571. MK-571 is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors but is ineffective at blocking LTC4 or LTD4activation of the recombinant human or murine CysLT2 receptors. MK-57 also acts as a specific inhibitor of multi-drug resistance protein-1 (MRP1).