MRL-24, Catalog: 2764

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(S)-2-(3-((1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

PRODUCT SUMMARY

Alternate Names (S)-2-(3-((1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

Appearance White solid

Molecular Formula C₂₈H₂₄F₃NO₆

Molecular Weight 527.49

Purity ≥ 98% by TLC

Solubility DMSO (~ 30 mg/ml)

SMILES CC1=C(CC2=CC(O[C@H](C(O)=O)C)=CC=C2)C3=CC(OC(F)(F)F)=CC=C3N1C(C4=CC=C(OC)C=C4)=O

InChi InChI=1S/C28H24F3NO6/c1-16-23(14-18-5-4-6-21(13-18)37-17(2)27(34)35)24-15-22(38-28(29,30)31)11-12-25(24)32(16)26(33)19-7-9-20(36-3)10-8-19/h4-13,15,17H,14H2,1-3H3,(H,34,35)

InChi Key OFCWBJAYEIROGZ-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Cell-permeable. MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.