RKI-1447, Catalog: 2472
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N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea
N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea
Alternate Names N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea
Appearance Yellow solid
CAS # 1342278-01-6
Molecular Formula C₁₆H₁₄N₄O₂S
Molecular Weight 326.37
Purity ≥ 98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES O=C(NCC1=CC=CC(O)=C1)NC2=NC(C3=CC=NC=C3)=CS2
InChi InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChi Key GDVRVPIXWXOKQO-UHFFFAOYSA-N
Storage Conditions -20°C
Shipping Conditions Gel Pack
Usage For Research Use Only! Not For Use in Humans.
Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.
A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors.