Retro-2, Catalog: 2516

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Retro-2(cycl); (±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one; Ricin retrograde transport blocker

PRODUCT SUMMARY

Alternate Names Retro-2(cycl); (±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one; Ricin retrograde transport blocker

Appearance Off-white solid

CAS # 1429192-00-6

Molecular Formula C₁₉H₁₆N₂OS

Molecular Weight 320.41

Purity ≥ 98% by HPLC

Solubility DMSO (~5 mg/ml)

SMILES O=C1N(C2=CC=CC=C2)C(C3=CC=C(C)S3)NC4=C1C=CC=C4

InChi InChI=1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3

InChi Key BOAPXDSRULBILC-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

An inhibitor of ribosome-inactivating proteins (RIPs). At a concentration of 200 mg/kg, Retro-2 displayed full protection of mice against a dose of ricin that killed 90% of an unprotected control mouse population. Blocks Leishmania parasitophorous vacuole (LPV) development. Retro-2 inhibited the replication of Leishmania parasites in axenic cultures.