Takinib, Catalog: B2324

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3-N-(1-Propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide

PRODUCT SUMMARY

Alternate Names 3-N-(1-Propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide

Appearance Crystalline solid

CAS # 1111556-37-6

Molecular Formula C₁₈H₁₈N₄O₂

Molecular Weight 322.36

Purity ≥ 98% by HPLC

Solubility >25 mg/ml in DMSO

SMILES CCCN1C2=CC=CC=C2N=C1NC(=O)C3=CC=CC(=C3)C(=O)N

InChi InChI=1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24)

InChi Key UOZVVPXKJGOFIG-UHFFFAOYSA-N

PubChem CID 37750349

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Takinib is a potent and selective TAK1 inhibitor (IC₅₀ = 9.5 nM). Sensitizes cells to TNF-α-induced cell death, with potential implications for cancer and autoimmune diseases.