TC-E 5003, Catalog: B1177

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N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide

PRODUCT SUMMARY

Alternate Names N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide

Appearance Off-white solid

CAS # 17328-16-4

Molecular Formula C₁₆H₁₄Cl₂N₂O₄S

Molecular Weight 401.26

Purity ≥ 98% by HPLC

Solubility DMSO (~20 mg/ml)

SMILES C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl

InChi InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)

InChi Key SHRCVZJKZJGIHQ-UHFFFAOYSA-N

PubChem CID 87052

MDL Number MFCD00028183

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells.