NSC-319726, Catalog: 9439

IN STOCK!
US$0.00

1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

PRODUCT SUMMARY

Alternate Names 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

Appearance White solid

CAS # 71555-25-4

Molecular Formula C₁₁H₁₄N₄S

Molecular Weight 234.32

Purity ≥ 98%

Solubility DMSO (>20 mg/ml)

SMILES CC(=NNC(=S)N1CCC1)C2=CC=CC=N2

InChi InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9-

InChi Key XDHBUMNIQRLHGO-LCYFTJDESA-N

PubChem CID 5921672

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.