(R)-Perharidine-1, Catalog: 2615

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(R)-2-((3-Isopropyl)-7-(4-pyridin-2-yl)benzylamino)-3H-imidazo[4,5-b]pyridine-5-yl)amino)butan-1-ol

PRODUCT SUMMARY

Alternate Names (R)-2-((3-Isopropyl)-7-(4-pyridin-2-yl)benzylamino)-3H-imidazo[4,5-b]pyridine-5-yl)amino)butan-1-ol

Appearance White to off-white solid

CAS # 1133437-80-5

Molecular Formula C₂₅H₃₀N₆O

Molecular Weight 430.55

Purity > 95% by NMR

Solubility DMSO or EtOH

SMILES CC[C@H](CO)NC1=CC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4C(N(C(C)C)C=N4)=N1

InChi InChI=1S/C25H30N6O/c1-4-20(15-32)29-23-13-22(24-25(30-23)31(16-28-24)17(2)3)27-14-18-8-10-19(11-9-18)21-7-5-6-12-26-21/h5-13,16-17,20,32H,4,14-15H2,1-3H3,(H2,27,29,30)/t20-/m1/s1

InChi Key VGHHVXRBOQENRA-HXUWFJFHSA-N

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

(R)-Perharidine-1 is a potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Also acts as a casein kinase 1 (CK1δ/ε) inhibitor. Inhibits the proliferation of various cancer cell lines.