GSK-1059615, Catalog: 9450

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5Z-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione

PRODUCT SUMMARY

Alternate Names 5Z-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione

Appearance Off-white solid

CAS # 958852-01-2

Molecular Formula C₁₈H₁₁N₃O₂S

Molecular Weight 333.36

Purity ≥ 98% by HPLC

Solubility DMSO (~4 mg/ml)

SMILES C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4

InChi InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-

InChi Key QDITZBLZQQZVEE-YBEGLDIGSA-N

PubChem CID 23582824

MDL Number MFCD18074517

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.