I-BET762, Catalog: 2628

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(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide; GSK525762

PRODUCT SUMMARY

Alternate Names (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide; GSK525762

Appearance Off-white solid

CAS # 1260907-17-2

Molecular Formula C₂₂H₂₂ClN₅O₂

Molecular Weight 423.9

Purity > 98% by HPLC

Solubility DMSO or EtOH

SMILES CCNC(=O)CC1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C

InChi nChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1

InChi Key AAAQFGUYHFJNHI-SFHVURJKSA-N

PubChem CID 46943432

Handling Protect from air and light

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell proliferation and suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation.