Cholesteryl Hemisuccinate, Catalog: B1978

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3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS

PRODUCT SUMMARY

Alternate Names 3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS

Appearance White to off-white solid

CAS # 1510-21-0

Molecular Formula C₃₁H₅₀O₄

Molecular Weight 486.73

Purity ≥ 95%

Solubility EtOH (warm; with faint turbidity)

SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C

InChi InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

InChi Key WLNARFZDISHUGS-MIXBDBMTSA-N

PubChem CID 65082

MDL Number MFCD00037705

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Cholesteryl hemisuccinate is a useful cholesterol-based detergent that increases the stability of G protein-coupled receptors (GPCRs). Together with mutagenesis studies and recent GPCR structures, it has been determined that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.