CX-6258, Catalog: 2851

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(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one

PRODUCT SUMMARY

Alternate Names (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one

Appearance White solid

CAS # 1202916-90-2

Molecular Formula C₂₆H₂₄ClN₃O₃

Molecular Weight 461.94

Purity ≥ 98% by HPLC

Solubility DMSO (>5 mg/ml)

SMILES CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O

InChi InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+

InChi Key KGBPLKOPSFDBOX-CJLVFECKSA-N

PubChem CID 44545852

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

CX-6258 is a potent pan-Pim kinases inhibitor (IC₅₀ values of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively). CX-6258 exhibits in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models.