Elesclomol (STA-4783), Catalog: B1815

Alternate Names  N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; STA4783

Appearance Crystalline solid

CAS # 488832-69-5 

Molecular Formula C₁₉H₂₀N₄O₂S₂

Molecular Weight 400.52

Purity ≥ 98% by HPLC

Solubility DMSO ( >20 mg/ml)

SMILES CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2

InChi InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)

InChi Key BKJIXTWSNXCKJH-UHFFFAOYSA-N

PubChem CID 300471

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Elesclomol is a novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. The mechanism underlying the proapoptotic activity of elesclomol is through the induction of ROS (reactive oxygen species) and oxidative stress. Elesclomol rapidly induces ROS in cancer cells, generating a transcription profile characteristic of an oxidative stress response.