CBHA, Catalog: 2284

Alternate Names N-hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-benzamide; m-Carboxycinnamic Acid bis-Hydroxamide

Peptide Sequence No

Appearance Crystalline solid

CAS # 174664-65-4

Molecular Formula C₁₀H₁₀N₂O₄

Molecular Weight 222.2

Purity ≥ 98%

Solubility DMSO

SMILES C1=CC(=CC(=C1)C(=O)NO)C=CC(=O)NO

InChi InChI=1S/C10H10N2O4/c13-9(11-15)5-4-7-2-1-3-8(6-7)10(14)12-16/h1-6,15-16H,(H,11,13)(H,12,14)/b5-4+

InChi Key OYKBQNOPCSXWBL-SNAWJCMRSA-N

PubChem CID 5353484

MDL Number MFCD03453553

Storage Conditions -20 ̊C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

A potent histone deacetylase (HDAC) inhibitor (ID₅₀ values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively). CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 μM) and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/ kg.