AR-42 (HDAC-42), Catalog: 2716

Alternate Names S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide

Appearance Crystalline solid

CAS # 935881-37-1

Molecular Formula C₁₈H₂₀N₂O₃

Molecular Weight 312.36

Purity ≥ 98% by HPLC

Solubility DMSO (~ 20 mg/ml) or EtOH (~ 20 mg/ml

SMILES CC(C)C(C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO

InChi InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1

InChi Key LAMIXXKAWNLXOC-INIZCTEOSA-N

PubChem CID 6918848

MDL Number MFCD17676151

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

AR-42 is a potent histone deacetylase inhibitor (HDACi). It induces growth inhibition, cell- cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 also promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21 and exhibits in vitro and ex vivo biologic activity against malignant mast cells.