HG-10-012-01, Catalog: 2604

Alternate Name [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

Appearance White to off-white solid

CAS # 1351758-81-0

Molecular Formula C₁₇H₂₀ClN₅O₃

Molecular Weight 377.83

Purity > 98% by HPLC

Solubility DMSO (>30 mg/ml)

SMILES O=C(N1CCOCC1)C(C=C2)=CC(OC)=C2NC3=NC=C(Cl)C(NC)=N3

InChi InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)

InChi Key YEVOZZZLKJKCCD-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells. May be a useful tool for Parkinson’s Disease research.