TG-101209, Catalog: B3220

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N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

PRODUCT SUMMARY

Alternate Names N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

Peptide Sequence N/A

Appearance White to off-white solid

CAS # 936091-14-4

Molecular Formula C₂₆H₃₅N₇O₂S

Molecular Weight 509.67

Purity ≥ 98% by HPLC

Solubility >10 mg/ml DMSO

SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C

InChi InChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30)

InChi Key JVDOKQYTTYUYDV-UHFFFAOYSA-N

PubChem CID 16722832

Handling Do not take internally. Wear gloves and a mask when handling the product! Avoid contact by all modes of exposure.

Storage Conditions -20ºC

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

TG101209 is a potent and selective inhibitor of Janus Kinase 2 (JAK2) (IC50 = 6 nM). It displays 28-fold selectivity over JAK3 (IC50 = 169 nM). TG101209 induces dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines.