Meisoindigo, Catalog: B1822

Alternate Names (E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione; Methyl isoindigotin; N-Methylisoindigotin; Meisoindigo; Dian III

Appearance Crystalline solid

CAS # 97207-47-1 

Molecular Formula C₁₇H₁₂N₂O₂

Molecular Weight 276.29

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES CN1C2=CC=CC=C2C(=C3C4=CC=CC=C4NC3=O)C1=O

InChi InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+

InChi Key QNOCRUSVMMAKSC-CCEZHUSRSA-N

PubChem CID 5479433

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of microtubules. It is also reported to have efficacy in acute myeloid leukemia. In the AML cell lines, HL-60, NB4 and U937, meisoindigo induces apoptosis in both caspase-dependent and -independent pathways.