Quisinostat hydrochloride, Catalog: B3066

Alternate Names N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide hydrochloride; JNJ-26481585

Appearance Solid

CAS # 1083078-98-1

Molecular Formula C₂₁H₂₇ClN₆O₂

Molecular Weight 430.93

Purity ≥ 98%

Solubility ~20 mg/ml in DMSO

SMILES CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl

InChi InChI=1S/C21H26N6O2.ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);1H

InChi Key TWNOICNTTFKOHQ-UHFFFAOYSA-N

PubChem CID 25067557

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad spectrum antiproliferative activity (IC₅₀ values of 3.1-246 nM) in lung, breast, colon, prostate, brain and ovarian cancer cell lines.