ELR-510444, Catalog: 9433

Alternate Names N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-benzenesulfonamide

Appearance Crystalline solid

CAS # 1233948-35-0

Molecular Formula C₁₉H₁₆N₂O₂S₂

Molecular Weight 368.5

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O

InChi InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3

InChi Key GRYXROIHHXHFND-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

ELR-510444 is a potent microtube disruptor with potential anticancer activity. It displays potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR-510444 potently inhibits cell proliferation with an IC₅₀ value of 30.9 nM in MDA-MB-231 cells, inhibits the rate and extent of purified tubulin assembly, and displaces colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.