Iron Chelator, Dp44MT, Catalog: 9634

Alternate Names 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide, Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone

Appearance Yellow to orange solid

CAS # 152095-12-0

Molecular Formula C₁₄H₁₅N₅S

Molecular Weight 285.37

Purity ≥ 98%

Solubility DMSO (>5 mg/ml)

SMILES CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2

InChi InChI=1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)

InChi Key XOBIGRNRXCAMJQ-UHFFFAOYSA-N

PubChem CID 10334137

MDL Number MFCD20527329

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Dp44MT is a cell-permeable iron chelator. This di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.