PTC-209, Catalog: B1055

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N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine

PRODUCT SUMMARY

Alternate Names N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine

Appearance Off-white solid

CAS # 315704-66-6

Molecular Formula C₁₇H₁₃Br₂N₅OS

Molecular Weight 495.19

Purity ≥ 98% by HPLC

Solubility DMSO (>40 mg/ml)

SMILES CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br

InChi InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23)

InChi Key XVOOCQSWCCRVDY-UHFFFAOYSA-N

PubChem CID 1117196

MDL Number MFCD02110649

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

PTC-209 is a potent, cell-permeable, BMI-1 inhibitor (IC₅₀ = 0.5 µM) with potential anticancer activity. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs). PTC-209 inhibits tumor growth and reduces the levels of CICs present in colon cancer tumor xenografts in mice.