Aftin-4, Catalog: 2574

Alternate Names N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4

Appearance White to off-white solid

CAS # 866893-90-5

Molecular Formula C₂₀H₂₈N₆O

Molecular Weight 368.48

Purity ≥ 98% by NMR

Solubility DMSO or EtOH

SMILES CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1

InChi InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1

InChi Key YPYWONAECUVKHY-MRXNPFEDSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Handling Protect from air and light

A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.