BAY-1436032, Catalog: B1570

Alternate Names 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid

Appearance Crystalline solid

CAS # 1803274-65-8

Molecular Formula C₂₆H₃₀F₃N₃O₃

Molecular Weight 489.5

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES O=C(O)CCC1=CC=C2N([C@H]3CC(C)(C)C[C@@H](C)C3)C(NC4=CC=C(OC(F)(F)F)C=C4)=NC2=C1

InChi InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)/t16-,19+/m0/s1

InChi Key RNMAUIMMNAHKQR-QFBILLFUSA-N

Handling Protect from air and light

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

BAY-1436032 is a potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. It is a selective inhibitor of the fibroblast growth factor receptor (FGFR) family of receptors, which play a role in cell signaling and growth regulation. BAY-1436032 inhibits the activity of specific fibroblast growth factor receptors (FGFR), which are involved in cell proliferation, angiogenesis, and tumor growth. By targeting FGFRs, BAY-1436032 aims to disrupt the signaling pathways that promote cancer cell growth and survival.