BAY 87-2243, Catalog: B1878

Alternate Names 5-(1-((2-(4-cyclopropylpiperazin-1-yl)pyridin-4-yl)methyl)-5-methyl-1H-pyrazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Appearance Crystalline solid

CAS # 1227158-85-1

Molecular Formula C₂₆H₂₆F₃N₇O₂

Molecular Weight 525.53

Purity ≥ 98% by HPLC

Solubility DMSO (>7 mg/ml)

SMILES CC1=CC(=NN1CC2=CC(=NC=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(C=C6)OC(F)(F)F

InChi InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3

InChi Key CDJNNOJINJAXPV-UHFFFAOYSA-N

PubChem CID 67377767

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which is involved in cellular responses to low oxygen levels (hypoxia). In tumors, areas of low oxygen concentration can promote tumor growth, metastasis, and resistance to conventional therapies. By targeting the HIF pathway, BAY 87-2243 aims to disrupt these tumor-promoting effects. Additionally, BAY 87-2243 also acts as an inhibitor of mitochondrial function. It can inhibit the oxygen consumption with IC₅₀ value of 10 nM.