BMS-794833, Catalog: B2055

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N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

PRODUCT SUMMARY

Alternate Names N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Appearance White to off-white solid

CAS # 1174046-72-0

Molecular Formula C₂₃H₁₅ClF₂N₄O₃

Molecular Weight 468.84

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F

InChi InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32)

InChi Key PDYXPCKITKHFOZ-UHFFFAOYSA-N

PubChem CID 44155856

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

BMS-794833 is a potent, ATP-competitive inhibitor of Met and VEGFR2 with IC₅₀ of 1.7 nM and 15 nM, respectively. It also inhibits Ron, Axl, and Flt-3 with IC₅₀ values <3 nM.