ORY-1001, Catalog: B1957

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N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine, dihydrochloride; RG-6016

PRODUCT SUMMARY

Alternate Names N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine, dihydrochloride; RG-6016

Appearance Crystalline solid

CAS # 1431326-61-2

Molecular Formula C₁₅H₂₄Cl₂N₂

Molecular Weight 303.27

Purity ≥ 98% by HPLC

Solubility DMSO (~7 mg/ml)

SMILES C1CC(CCC1N)NC2CC2C3=CC=CC=C3.Cl.Cl

InChi InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1

InChi Key UCINOBZMLCREGM-RNNUGBGQSA-N

PubChem CID 71664305

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

ORY-1001 is a potent and selective inhibitor of LSD1 (IC₅₀ < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.