Anastrozole, Catalog: B2177

Alternate Names α1,α1,α3,α3-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; ZD1033; Anastrol

Appearance White solid

CAS # 120511-73-1

Molecular Formula C₁₇H₁₉N₅

Molecular Weight 293.4

Purity ≥ 97% by HPLC

Solubility DMSO (>10 mg/ml)

SMILES CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N

InChi InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChi Key YBBLVLTVTVSKRW-UHFFFAOYSA-N

PubChem CID 2187

MDL Number MFCD00866298

Handling Protect from air and light

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Anastrozole is a potent aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. By lowering estrogen levels, it prevents estrogen from fueling the growth of hormone-sensitive breast cancer cells. Anastrozole inhibits human placental aromatase in vitro with an IC₅₀ value of 15 nM. At doses 100-200 times its maximally effective aromatase inhibitory dose, it does not interfere with the biosynthesis of other steroids, including cholesterol, cortisol, and aldosterone.