STF-62247, Catalog: B2210

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N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

PRODUCT SUMMARY

Alternate Names N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

Appearance Off-white solid

CAS # 315702-99-9

Molecular Formula C₁₅H₁₃N₃S

Molecular Weight 267.35

Purity ≥ 98% by HPLC

Solubility DMSO (>25 mg/ml)

SMILES CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3

InChi InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChi Key KATNUHQNJGNLPW-UHFFFAOYSA-N

PubChem CID 704473

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC₅₀ = 625 nM). STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL.