Destruxin A, Catalog: B2947

Alternate Names 3-(butan-2-yl)-5,8,9-trimethyl-6-(propan-2-yl)-16-(prop-2-en-1-yl)dodecahydropyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine-1,4,7,10,14,17(11h,16h)-hexone; (3S,6S,9S,16R,21aS)-16-Allyl-3-[(2S)-2-butanyl]-6-isopropyl-5,8,9-trimethyldodecahydropyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexone; NSC361126

Appearance Solid

CAS # 6686-70-0

Molecular Formula C₂₉H₄₇N₅O₇

Molecular Weight 577.71

Purity ≥ 96%

Solubility 10 mg/ml in DMSO

SMILES CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC=C)C)C)C(C)C)C

InChi InChI=1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)

InChi Key XIYSEKITPHTMJT-UHFFFAOYSA-N

PubChem CID 122810

Storage Conditions -20ºC

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A exerts its toxic effects by interacting with specific receptors on insect cell membranes. This interaction disrupts the cellS normal ion balance and leads to the formation of pores in the membrane, ultimately causing cell death. Destruxin A suppresses the Drosophila humoral immune response in Drosophila melanogaster. It increases peptidoglycan recognition protein (PGRP), prophenoloxidase (proPO) system and affects diverse pathways, including apoptosis, calcium signaling, and development in the larvae of Plutella xylostella.