Sodium dichloroacetate, Catalog: B3080

Alternate Names Sodium;2,2-dichloroacetate; Dichloroacetic acid sodium salt; CPC 211; Ceresine

Appearance White Solid

CAS # 2156-56-1

Molecular Formula C₂HCl₂NaO₂

Molecular Weight 150.92

Purity ≥ 98%

Solubility ~7.5 mg/ml in ethanol, ~15 mg/ml in water, ~15 mg/ml in DMSO

SMILES C(C(=O)[O-])(Cl)Cl.[Na+]

InChi InChI=1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChi Key LUPNKHXLFSSUGS-UHFFFAOYSA-M

PubChem CID 517326

MDL Number MFCD00070489

Storage Conditions -20ºC

Shipping Conditions RT

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Sodium dichloroacetate is an inhibitor of pyruvate dehydrogenase kinase (PDK). It shows IC₅₀ values of 183 μM and 80 μM for PDK2 and PDK4 respectively. DCA causes apoptosis in cancer cells and inhibits tumor growth. DCA works by targeting the mitochondria of cancer cells. It activates an enzyme called PDK, which in turn leads to the increased activity of the pyruvate dehydrogenase complex (PDC). This metabolic shift promotes mitochondrial function and encourages cancer cells to undergo apoptosis, ultimately inhibiting their growth.