Salermide, Catalog: 1873

Alternate Names N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide.

Appearance Yellow solid

CAS # 1105698-15-4

Molecular Formula C₂₆H₂₂N₂O₂

Molecular Weight 394.47

Purity ≥ 98%

Solubility DMSO (100 mM)

SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43

InChi InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,27H,1H3,(H,28,30)/b24-17-

InChi Key UADRPWLRVLBVBC-ULJHMMPZSA-N

PubChem CID 42626405

MDL Number MFCD12912446

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear gloves and a mask when handling the product! Protect from air and moisture.

Salermide is a cell permeable, small molecule compound that belongs to the class of sirtuin inhibitors. Sirtuins are a family of enzymes involved in various cellular processes, including gene regulation, DNA repair, metabolism, and aging. Salermide specifically targets Sirtuin 1 (SIRT1) and inhibits its activity. Salermide works by inhibiting the enzymatic activity of SIRT1. SIRT1 is a NAD+-dependent histone deacetylase that regulates gene expression and cellular processes through deacetylation of histones and non-histone proteins. By inhibiting SIRT1, Salermide disrupts the deacetylation process and can potentially affect the regulation of gene expression and cellular functions associated with SIRT1 activity.